human CCNL2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CCNL2.
shADV-233874
Ad-h-CCNL2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CCNL2 (cyclin L2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ANIA-6B; CCNM; CCNS; cyclin M; cyclin S; cyclin-L2; HCLA-ISO; HLA-ISO; paneth cell-enhanced expression protein; PCEE; SB138
Description (eCommerce)
Cyclin L2 is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression and transcription. The hallmark characteristic of cyclins is the periodicity of their expression and activity that is regulated transcriptionally and post-transcriptionally via phosphorylation and ubiquitination. Cyclin L2 is part of a group of cyclins that are involved in transcriptional regulation at the level of RNA transcription, initiation, elongation, and RNA processing. The transcriptional regulating cyclins include cyclin C, H, K, L1, L2, T1, and T2 which associate with CDK7, -8, -9, -10 and -12. Cyclin L2 associates with CDK11 and RNA polymerase II and co-localizes with splicing factors and is implicated to play a role in pre-mRNA splicing.
Description (Vector)
CCNL2 belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
81669
Gene Name (eCommerce)
cyclin L2
Gene Name (Vector)
cyclin L2
Gene Symbol
CCNL2
HGNC ID
HGNC:20570
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
681
ORF Size (bp)
681 bp
Protein Name (eCommerce)
Cyclin-L2
RefSeq ID
NM_030937
RefSeq Synonyms
NM_030937, NM_001320155, NM_001320153, NM_001039577, BC016333,
Research Areas
RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Cyclin L2 is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression and transcription. The hallmark characteristic of cyclins is the periodicity of their expression and activity that is regulated transcriptionally and post-transcriptionally via phosphorylation and ubiquitination. Cyclin L2 is part of a group of cyclins that are involved in transcriptional regulation at the level of RNA transcription, initiation, elongation, and RNA processing. The transcriptional regulating cyclins include cyclin C, H, K, L1, L2, T1, and T2 which associate with CDK7, -8, -9, -10 and -12. Cyclin L2 associates with CDK11 and RNA polymerase II and co-localizes with splicing factors and is implicated to play a role in pre-mRNA splicing.
UniProt ID (eCommerce)
Q96S94
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.