human PANK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PANK2.
shADV-233005
Ad-h-PANK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PANK2 (pantothenate kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C20orf48; HARP; HSS; NBIA1; PKAN
Description (Vector)
PANK2 encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
Gene ID
80025
Gene Name (Vector)
pantothenate kinase 2
Gene Symbol
PANK2
HGNC ID
HGNC:15894
ORF Size (aa)
1713
ORF Size (bp)
1713 bp
RefSeq ID
NM_024960
RefSeq Synonyms
NM_153640, NM_153638, NM_024960, NM_001324193, NM_001324192, NM_001324191, BC009421,
Species
human
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.