human ACO2 shRNA silencing Adenovirus

Name 
Ad-h-ACO2-shRNA
Cat No 
shADV-230719
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ACO2.

shADV-230719
Ad-h-ACO2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ACO2 (aconitase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Aconitase; aconitase 2, mitochondrial; aconitate hydratase, mitochondrial; ACONM; citrate hydro-lyase; epididymis secretory sperm binding protein Li 284; HEL-S-284; ICRD; mitochondrial aconitase; OCA8; OPA9
Description (eCommerce)
Aconitase belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification [[taken from NCBI Entrez Gene (Gene ID: 50)].
Description (Vector)
ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
Gene ID
50
Gene Name (eCommerce)
aconitase 2
Gene Name (Vector)
aconitase 2
Gene Symbol
ACO2
HGNC ID
HGNC:118
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2343
ORF Size (bp)
2343 bp
Protein Name (eCommerce)
Aconitate hydratase, mitochondrial
RefSeq ID
NM_001098
RefSeq Synonyms
NM_001098, BC026196, BC014092,
Research Areas
Apoptosis,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration
Research Areas (Faceted)
cell_biology,metabolism,neurobiology
Species
human
Target Sentence
Aconitase belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification [[taken from NCBI Entrez Gene (Gene ID: 50)].
UniGene ID
Hs.643610
UniProt ID (eCommerce)
Q99798

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.