human CCDC22 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CCDC22.
shADV-230283
Ad-h-CCDC22-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CCDC22 (coiled-coil domain containing 22). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
coiled-coil domain-containing protein 22; CXorf37; JM1; RTSC2
Description (eCommerce)
CCDC22 is involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60826].
Description (Vector)
CCDC22 encodes a protein containing a coiled-coil domain. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. Localization of the orthologous rat protein suggests that it may play a role in neuronal injury response. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability.
Gene ID
28952
Gene Name (eCommerce)
coiled-coil domain containing 22
Gene Name (Vector)
coiled-coil domain containing 22
Gene Symbol
CCDC22
HGNC ID
HGNC:28909
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1884
ORF Size (bp)
1884 bp
Protein Name (eCommerce)
Coiled-coil domain-containing protein 22
RefSeq ID
NM_014008
RefSeq Synonyms
NM_014008, BC011675, BC000972,
Research Areas
Neurobiology
Research Areas (Faceted)
neurobiology
Species
human
Target Sentence
CCDC22 is involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60826].
UniGene ID
Hs.26333
UniProt ID (eCommerce)
O60826
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.