human SIN3A shRNA silencing Adenovirus

Name 
Ad-h-SIN3A-shRNA
Cat No 
shADV-229994
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SIN3A.

shADV-229994
Ad-h-SIN3A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SIN3A (SIN3 transcription regulator family member A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
histone deacetylase complex subunit Sin3a; paired amphipathic helix protein Sin3a; SIN3 homolog A, transcription regulator; transcriptional corepressor Sin3a; transcriptional co-repressor Sin3A; transcriptional regulator, SIN3A; WITKOS
Description (eCommerce)
Sin3A is a part of a histone deacetylase co-repressor complex that functions to stabilize complex members and regulate gene expression through deacetylation of histones. Sin3A acts as a scaffold for a core complex which contains HDAC1, HDAC2, RbAp46, RbAp48, SAP30, RBP1 and p33INHib. Sin3A also associates with the Mad/Max complex to mediate transcriptional repression.
Description (Vector)
SIN3A is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Gene ID
25942
Gene Name (eCommerce)
SIN3 transcription regulator family member A
Gene Name (Vector)
SIN3 transcription regulator family member A
Gene Symbol
SIN3A
HGNC ID
HGNC:19353
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3822
ORF Size (bp)
3822 bp
Protein Name (eCommerce)
Paired amphipathic helix protein Sin3a
RefSeq ID
NM_015477
RefSeq Synonyms
NM_015477, NM_001145358, NM_001145357, BC137099, BC137098, BC066364,
Research Areas
Aging,Apoptosis,Cancer,Cell Cycle,DNA Replication,Epigenetic Regulation of Gene Expression,Hedgehog Signaling,Huntington's Disease,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Signal Transduction,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Sin3A is a part of a histone deacetylase co-repressor complex that functions to stabilize complex members and regulate gene expression through deacetylation of histones. Sin3A acts as a scaffold for a core complex which contains HDAC1, HDAC2, RbAp46, RbAp48, SAP30, RBP1 and p33INHib. Sin3A also associates with the Mad/Max complex to mediate transcriptional repression.
UniGene ID
Hs.513039
UniProt ID (eCommerce)
Q96ST3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.