human EVI5 shRNA silencing Adenovirus

Name 
Ad-h-EVI5-shRNA
Cat No 
shADV-229849
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EVI5.

shADV-229849
Ad-h-EVI5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EVI5 (ecotropic viral integration site 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
dJ846D11.1 (ecotropic viral integration site 5); ecotropic viral integration site 5 protein homolog; EVI-5; NB4S; neuroblastoma stage 4S gene protein
Description (eCommerce)
The EVI5 oncogene has been identified as a protein that is localized to the centrosome and mitotic spindle, and in association with the aurora B complex, facilitates cytokinesis. EVI5 also appears to prevent premature APC/C activation and mitotic progression by stabilizing the anaphase-promoting complex/cyclosome (APC/C) inhibitor, Emi1, as well as cyclin A. EVI5 has also been demonstrated to be a binding partner of the Rab11 GTPase that regulates intracellular transport and cytokinesis.
Gene ID
7813
Gene Name (eCommerce)
ecotropic viral integration site 5
Gene Name (Vector)
ecotropic viral integration site 5
Gene Symbol
EVI5
HGNC ID
HGNC:3501
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2430
ORF Size (bp)
2430 bp
Protein Name (eCommerce)
Ecotropic viral integration site 5 protein homolog
RefSeq ID
NM_005665
RefSeq Synonyms
NM_005665, NM_001308248, BC156793, BC141544,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
The EVI5 oncogene has been identified as a protein that is localized to the centrosome and mitotic spindle, and in association with the aurora B complex, facilitates cytokinesis. EVI5 also appears to prevent premature APC/C activation and mitotic progression by stabilizing the anaphase-promoting complex/cyclosome (APC/C) inhibitor, Emi1, as well as cyclin A. EVI5 has also been demonstrated to be a binding partner of the Rab11 GTPase that regulates intracellular transport and cytokinesis.
UniGene ID
Hs.594434
UniProt ID (eCommerce)
O60447

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.