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human GPSM2 shRNA silencing Adenovirus

Name 
Ad-h-GPSM2-shRNA
Cat No 
shADV-229275
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GPSM2.

shADV-229275
Ad-h-GPSM2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GPSM2 (G-protein signaling modulator 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CMCS; DFNB82; G-protein signalling modulator 2 (AGS3-like, C. elegans); G-protein-signaling modulator 2; LGN; mosaic protein LGN; PINS
Description (eCommerce)
LGN (Leu-Gly-Asn repeat-enriched protein) plays an important role in spindle pole orientation. LGN interacts and contributes to the functional activity of G(i) alpha proteins. LGN acts to stabilize the apical complex during neuroblast divisions.
Description (Vector)
GPSM2 belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).
Gene ID
29899
Gene Name (eCommerce)
G protein signaling modulator 2
Gene Name (Vector)
G-protein signaling modulator 2
Gene Symbol
GPSM2
HGNC ID
HGNC:29501
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2034
ORF Size (bp)
2034 bp
Protein Name (eCommerce)
G-protein-signaling modulator 2
RefSeq ID
NM_013296
RefSeq Synonyms
NM_013296, NM_001321039, NM_001321038, BC027732,
Research Areas
Cell Cycle,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
LGN (Leu-Gly-Asn repeat-enriched protein) plays an important role in spindle pole orientation. LGN interacts and contributes to the functional activity of G(i) alpha proteins. LGN acts to stabilize the apical complex during neuroblast divisions.
UniGene ID
Hs.584901
UniProt ID (eCommerce)
P81274

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.