human ZWINT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ZWINT.
shADV-229016
Ad-h-ZWINT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ZWINT (ZW10 interacting kinetochore protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
human ZW10 interacting protein-1; HZwint-1; KNTC2AP; SIP30; SNAP25 interacting protein of 30 kDa; ZW10 interactor; ZW10 interactor, kinetochore protein; ZW10-interacting protein 1; ZWINT1; zwint-1
Description (eCommerce)
Yeast 2-hybrid and localization studies show that human ZW10 interacting protein 1 (ZWINT-1) interacts with HZw10 in active centromeres and may play a role in directing HZw10 to the kinetochore during prometaphase. HZw10 is a component of the mitotic checkpoint that associates with the kinetochore to ensure chromosome fidelity during cell division.
Description (Vector)
ZWINT encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
11130
Gene Name (eCommerce)
ZW10 interacting kinetochore protein
Gene Name (Vector)
ZW10 interacting kinetochore protein
Gene Symbol
ZWINT
HGNC ID
HGNC:13195
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
834
Protein Name (eCommerce)
ZW10 interactor
RefSeq ID
NM_007057
RefSeq Synonyms
NM_032997, NM_007057, NM_001005413, BC110399, BC020979,
Research Areas
Cell Cycle,Cell Division,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
Yeast 2-hybrid and localization studies show that human ZW10 interacting protein 1 (ZWINT-1) interacts with HZw10 in active centromeres and may play a role in directing HZw10 to the kinetochore during prometaphase. HZw10 is a component of the mitotic checkpoint that associates with the kinetochore to ensure chromosome fidelity during cell division.
UniGene ID
Hs.591363
UniProt ID (eCommerce)
O95229
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.