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human XPO5 shRNA silencing Adenovirus

Name 
Ad-h-XPO5-shRNA
Cat No 
shADV-227917
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human XPO5.

shADV-227917
Ad-h-XPO5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human XPO5 (exportin 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
exp5; exportin-5; ran-binding protein 21
Description (eCommerce)
Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exportin-5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HAV4].
Description (Vector)
XPO5 encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process.
Gene ID
57510
Gene Name (eCommerce)
exportin 5
Gene Name (Vector)
exportin 5
Gene Symbol
XPO5
HGNC ID
HGNC:17675
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3615
ORF Size (bp)
3615 bp
Protein Name (eCommerce)
Exportin-5
RefSeq ID
NM_020750
RefSeq Synonyms
NM_020750, BC062635, BC009969, BC000129,
Research Areas
Gene Expression,MicroRNAs in Cancer,RNA Binding,RNA Transport,Transport,tRNA Binding
Research Areas (Faceted)
cancer,genetics,transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exportin-5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HAV4].
UniGene ID
Hs.203206
UniProt ID (eCommerce)
Q9HAV4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.