human WRB shRNA silencing Adenovirus

Name
Ad-h-WRB-shRNA

Cat No
shADV-227843

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human WRB.

shADV-227843

Ad-h-WRB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human WRB (tryptophan rich basic protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CHD5; GET1

Description (Vector)

WRB encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

7485

Gene Name (Vector)

tryptophan rich basic protein

Gene Symbol

WRB

HGNC ID

HGNC:12790

ORF Size (aa)

525

RefSeq ID

NM_004627

RefSeq Synonyms

NM_004627, NM_001146218, BC012415,

Species

human

UniGene ID

Hs.198308

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.