human WARS shRNA silencing Adenovirus

Name 
Ad-h-WARS-shRNA
Cat No 
shADV-227593
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human WARS.

shADV-227593
Ad-h-WARS-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human WARS (tryptophanyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; GAMMA-2; HMN9; hWRS; IFI53; IFP53; interferon-induced protein 53; trpRS; tryptophan tRNA ligase 1, cytoplasmic; tryptophan--tRNA ligase, cytoplasmic; Tryptophanyl-tRNA synthetase
Description (eCommerce)
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family [taken from NCBI Entrez Gene (Gene ID: 7453)].
Description (Vector)
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.
Gene ID
7453
Gene Name (eCommerce)
tryptophanyl-tRNA synthetase
Gene Name (Vector)
tryptophanyl-tRNA synthetase
Gene Symbol
WARS
HGNC ID
HGNC:12729
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1416
ORF Size (bp)
1416 bp
Protein Name (eCommerce)
Tryptophan--tRNA ligase, cytoplasmic
RefSeq ID
NM_004184
RefSeq Synonyms
NM_213646, NM_213645, NM_173701, NM_004184, BC095453, BC017489,
Research Areas
Angiogenesis,Gene Expression,Metabolism/Metabolic Process,Translational Control
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,metabolism,transcription_translation
Species
human
Target Sentence
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family [taken from NCBI Entrez Gene (Gene ID: 7453)].
UniGene ID
Hs.497599
UniProt ID (eCommerce)
P23381

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.