human VAV3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human VAV3.
shADV-227417
Ad-h-VAV3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human VAV3 (vav guanine nucleotide exchange factor 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Description (eCommerce)
Vav3 is a member of the VAV guanine nucleotide exchange factor (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav3 acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases [taken from NCBI Entrez Gene (Gene ID: 10451)].
Description (Vector)
VAV3 is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. VAV3 product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
10451
Gene Name (eCommerce)
vav guanine nucleotide exchange factor 3
Gene Name (Vector)
vav guanine nucleotide exchange factor 3
Gene Symbol
VAV3
HGNC ID
HGNC:12659
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2541
ORF Size (bp)
2541 bp
Protein Name (eCommerce)
Guanine nucleotide exchange factor VAV3
RefSeq ID
NM_006113
RefSeq Synonyms
NM_006113, NM_001079874, BC156726, BC146365, BC143969,
Research Areas
Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cytoskeleton,DNA Damage/Repair,EGFR Signaling,Fc Receptor Signaling,GPCR Signaling,Immunology,Innate Immunity,Neurobiology,NGF Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Vav3 is a member of the VAV guanine nucleotide exchange factor (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav3 acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases [taken from NCBI Entrez Gene (Gene ID: 10451)].
UniGene ID
Hs.267659
UniProt ID (eCommerce)
Q9UKW4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.