human UGT1A1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human UGT1A1.
shADV-227140
Ad-h-UGT1A1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human UGT1A1 (UDP glucuronosyltransferase family 1 member A1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BILIQTL1; GNT1; HUG-BR1; UDPGT; UDPGT 1-1; UGT1; UGT1A
Description (Vector)
UGT1A1 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A1 is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Gene ID
54658
Gene Name (Vector)
UDP glucuronosyltransferase family 1 member A1
Gene Symbol
UGT1A1
HGNC ID
HGNC:12530
ORF Size (aa)
1602
ORF Size (bp)
1602 bp
RefSeq ID
NM_000463
RefSeq Synonyms
NM_000463, BC128415, BC128414,
Species
human
UniGene ID
Hs.554822
Recently Viewed Products
Ad-h-YES1-shRNA
Cat No: shADV-227964
Ad-h-LDLRAD3-shRNA
Cat No: shADV-213803
AAV-h-PIH1D1-shRNA
Cat No: shAAV-218934
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.