human TTL shRNA silencing Adenovirus

Name 
Ad-h-TTL-shRNA
Cat No 
shADV-226738
Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human TTL.

shADV-226738
Ad-h-TTL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TTL (tubulin tyrosine ligase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 (PubMed 14571137)).(supplied by OMIM, Mar 2008)
Gene ID
150465
Gene Name (Vector)
tubulin tyrosine ligase
Gene Symbol
TTL
HGNC ID
HGNC:21586
ORF Size (aa)
1134
RefSeq ID
NM_153712
RefSeq Synonyms
NM_153712, BC036819,
Species
human
UniGene ID
Hs.358997

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.