human TSN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TSN.
shADV-226614
Ad-h-TSN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TSN (translin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BCLF-1; C3PO; component 3 of promoter of RISC; RCHF1; recombination hotspot associated factor; recombination hotspot-binding protein; REHF-1; TBRBP; testis brain-RNA binding protein; translin; TRSLN
Description (eCommerce)
Translin (TSN) is a DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Translin seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15631].
Description (Vector)
TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.
Gene ID
7247
Gene Name (eCommerce)
translin
Gene Name (Vector)
translin
Gene Symbol
TSN
HGNC ID
HGNC:12379
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
687
Protein Name (eCommerce)
Translin
RefSeq ID
NM_004622
RefSeq Synonyms
NM_004622, NM_001261401, BC002359,
Research Areas
mRNA Binding,RNA Binding
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Translin (TSN) is a DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Translin seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15631].
UniGene ID
Hs.75066
UniProt ID (eCommerce)
Q15631
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.