human TRIM28 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TRIM28.
shADV-226420
Ad-h-TRIM28-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TRIM28 (tripartite motif containing 28). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E3 SUMO-protein ligase TRIM28; KAP1; KAP-1; KRAB Kruppel-associated box domain-associated protein 1; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; nuclear corepressor KAP-1; PPP1R157; protein phosphatase 1, regulatory subunit 157; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; RNF96; TF1B; TIF1B; TIF1-beta; transcription intermediary factor 1-beta; transcriptional intermediary factor 1-beta; Tripartite motif-containing protein 28
Description (eCommerce)
KAP-1 (KRAB-Associated Protein 1) is a member of the tripartite motif RBCC/Trim domain family that contains a RING finger domain, B boxes, and an alpha helical coiled coil region. KAP-1 functions as a corepressor by interacting with the KRAB domain of KRAB zinc-finger transcriptional repressors. KAP-1 also appears to function as a scaffold for chromatin-remodeling complexes involved in transcriptional repression.
Description (Vector)
TRIM28 mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Gene ID
10155
Gene Name (eCommerce)
tripartite motif containing 28
Gene Name (Vector)
tripartite motif containing 28
Gene Symbol
TRIM28
HGNC ID
HGNC:16384
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2262
ORF Size (bp)
2262 bp
Protein Name (eCommerce)
Transcription intermediary factor 1-beta
RefSeq ID
NM_005762
RefSeq Synonyms
NM_005762, BC052986, BC004978,
Research Areas
Chromatin Remodeling,DNA Damage/Repair,Gene Expression,Kinase/Phosphatase,p53 Signaling,Phospho-specific,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
KAP-1 (KRAB-Associated Protein 1) is a member of the tripartite motif RBCC/Trim domain family that contains a RING finger domain, B boxes, and an alpha helical coiled coil region. KAP-1 functions as a corepressor by interacting with the KRAB domain of KRAB zinc-finger transcriptional repressors. KAP-1 also appears to function as a scaffold for chromatin-remodeling complexes involved in transcriptional repression.
UniGene ID
Hs.467408
UniProt ID (eCommerce)
Q13263
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.