human TRAF4 shRNA silencing Adenovirus

Name 
Ad-h-TRAF4-shRNA
Cat No 
shADV-226332
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TRAF4.

shADV-226332
Ad-h-TRAF4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TRAF4 (TNF receptor associated factor 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CART1; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; RING finger protein 83; RNF83; TNF receptor-associated factor 4; TRAF4 variant 6; tumor necrosis receptor-associated factor 4A
Description (eCommerce)
TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. TRAF4 seems to mediate activation of NF-kappa-B and JNK and to be involved in apoptosis. TRAF4 may play a role in the development of respiratory tract. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUZ4].
Description (Vector)
TRAF4 encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
Gene ID
9618
Gene Name (eCommerce)
TNF receptor associated factor 4
Gene Name (Vector)
TNF receptor associated factor 4
Gene Symbol
TRAF4
HGNC ID
HGNC:12034
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1413
ORF Size (bp)
1413 bp
Protein Name (eCommerce)
TNF receptor-associated factor 4
RefSeq ID
NM_004295
RefSeq Synonyms
NM_004295, BC001769,
Research Areas
Apoptosis,Cancer,Cytoskeleton,JNK Signaling,Lung Cancer,Signal Transduction,TNF Signaling,Zinc-finger
Research Areas (Faceted)
cancer,signal_transduction,cell_biology
Species
human
Target Sentence
TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. TRAF4 seems to mediate activation of NF-kappa-B and JNK and to be involved in apoptosis. TRAF4 may play a role in the development of respiratory tract. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUZ4].
UniGene ID
Hs.8375
UniProt ID (eCommerce)
Q9BUZ4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.