human TPMT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TPMT.
shADV-226280
Ad-h-TPMT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TPMT (thiopurine S-methyltransferase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TPMTD
Description (Vector)
TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Gene ID
7172
Gene Name (Vector)
thiopurine S-methyltransferase
Gene Symbol
TPMT
HGNC ID
HGNC:12014
ORF Size (aa)
738
RefSeq ID
NM_000367
RefSeq Synonyms
NM_001346818, NM_001346817, NM_000367, BC009596, BC005339,
Species
human
UniGene ID
Hs.444319
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.