human TNNT3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TNNT3.
shADV-226144
Ad-h-TNNT3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TNNT3 (troponin T3, fast skeletal type). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TNTF
Description (Vector)
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).
Gene ID
7140
Gene Name (Vector)
troponin T3, fast skeletal type
Gene Symbol
TNNT3
HGNC ID
HGNC:11950
ORF Size (aa)
771
RefSeq ID
NM_006757
RefSeq Synonyms
NM_006757, NM_001297646, NM_001042782, NM_001042781, NM_001042780, BC171727, BC143537, BC117327,
Species
human
UniGene ID
Hs.73454
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.