Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human TNNI3 shRNA silencing Adenovirus

Name 
Ad-h-TNNI3-shRNA
Cat No 
shADV-226132
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TNNI3.

shADV-226132
Ad-h-TNNI3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TNNI3 (troponin I3, cardiac type). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Cardiac troponin I;cardiomyopathy, dilated 2A (autosomal recessive);CMD1FF;CMD2A;CMH7;cTnI;RCM1;TNNC1;troponin I type 3 (cardiac);troponin I, cardiac muscle
Description (eCommerce)
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The Troponin I subfamily contains three genes: Troponin I-skeletal-fast-twitch, Troponin I-skeletal-slow-twitch, and Troponin I-cardiac. Troponin I-cardiac is exclusively expressed in cardiac muscle tissues. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19429].
Description (Vector)
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Gene ID
7137
Gene Name (eCommerce)
troponin I3, cardiac type
Gene Name (Vector)
troponin I3, cardiac type
Gene Symbol
TNNI3
HGNC ID
HGNC:11947
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
633
Protein Name (eCommerce)
Troponin I, cardiac muscle
RefSeq ID
NM_000363
RefSeq Synonyms
NM_000363, BC099631, BC096167, BC096166, BC096165,
Research Areas
Cardiac Development,Cardiology,Cardiomyopathy,Cardiovascular
Research Areas (Faceted)
cardiovascular,developmental_biology
Species
human
Target Sentence
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The Troponin I subfamily contains three genes: Troponin I-skeletal-fast-twitch, Troponin I-skeletal-slow-twitch, and Troponin I-cardiac. Troponin I-cardiac is exclusively expressed in cardiac muscle tissues. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19429].
UniGene ID
Hs.709179
UniProt ID (eCommerce)
P19429

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.