human TNIK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TNIK.
shADV-226117
Ad-h-TNIK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TNIK (TRAF2 and NCK interacting kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MRT54; TRAF2 and NCK-interacting protein kinase
Description (eCommerce)
TNIK (TRAF2 and NCK-interacting protein kinase) is a serine threonine kinase that acts as an essential activator of the Wnt signaling pathway. TNIK is recruited to promoters of Wnt target genes and is required to activate Wnt target genes expression. TNIK may also play a role in the response to environmental stress and appears to act upstream of the JUN N-terminal pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UKE5].
Description (Vector)
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 (PubMed 10521462)).(supplied by OMIM, Mar 2008)
Gene ID
23043
Gene Name (eCommerce)
TRAF2 and NCK interacting kinase
Gene Name (Vector)
TRAF2 and NCK interacting kinase
Gene Symbol
TNIK
HGNC ID
HGNC:30765
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4083
ORF Size (bp)
4083 bp
Protein Name (eCommerce)
TRAF2 and NCK-interacting protein kinase
RefSeq ID
NM_015028
RefSeq Synonyms
NM_015028, NM_001161566, NM_001161565, NM_001161564, NM_001161563, NM_001161562, NM_001161561, NM_001161560, BC150256,
Research Areas
Cytoskeleton,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction,TNF Signaling,Wnt Signaling
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
TNIK (TRAF2 and NCK-interacting protein kinase) is a serine threonine kinase that acts as an essential activator of the Wnt signaling pathway. TNIK is recruited to promoters of Wnt target genes and is required to activate Wnt target genes expression. TNIK may also play a role in the response to environmental stress and appears to act upstream of the JUN N-terminal pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UKE5].
UniGene ID
Hs.34024
UniProt ID (eCommerce)
Q9UKE5
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.