human TNFSF8 shRNA silencing Adenovirus

Name 
Ad-h-TNFSF8-shRNA
Cat No 
shADV-226113
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TNFSF8.

shADV-226113
Ad-h-TNFSF8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TNFSF8 (tumor necrosis factor superfamily member 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD153; CD30L; CD30LG; TNLG3A
Description (Vector)
TNFSF8 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
944
Gene Name (Vector)
tumor necrosis factor superfamily member 8
Gene Symbol
TNFSF8
HGNC ID
HGNC:11938
ORF Size (aa)
705
RefSeq ID
NM_001244
RefSeq Synonyms
NM_001252290, NM_001244, BC111939, BC093630,
Species
human
UniGene ID
Hs.654445

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.