human TNFSF11 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TNFSF11.
shADV-226097
Ad-h-TNFSF11-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TNFSF11 (tumor necrosis factor superfamily member 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
Description (Vector)
TNFSF11 encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Gene ID
8600
Gene Name (Vector)
tumor necrosis factor superfamily member 11
Gene Symbol
TNFSF11
HGNC ID
HGNC:11926
ORF Size (aa)
954
RefSeq ID
NM_033012
RefSeq Synonyms
NM_033012, NM_003701, BC117288, BC117286, BC074890, BC074823,
Species
human
UniGene ID
Hs.333791
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.