Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human TMED10 shRNA silencing Adenovirus

Name 
Ad-h-TMED10-shRNA
Cat No 
shADV-225672
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TMED10.

shADV-225672
Ad-h-TMED10-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TMED10 (transmembrane p24 trafficking protein 10). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; p23; p24 family protein delta-1; P24(DELTA); p24d1; p24delta; p24delta1; S31I125; S31III125; testicular tissue protein Li 206; TMP21; Tmp-21-I; transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; transmembrane protein Tmp21
Description (eCommerce)
Transmembrane emp24 domain-containing protein 10 (TMED10) is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity [taken from NCBI Entrez Gene (Gene ID: 10972)].
Description (Vector)
TMED10 is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. TMED10 has a pseudogene on chromosome 8.
Gene ID
10972
Gene Name (eCommerce)
transmembrane p24 trafficking protein 10
Gene Name (Vector)
transmembrane p24 trafficking protein 10
Gene Symbol
TMED10
HGNC ID
HGNC:16998
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
660
Protein Name (eCommerce)
Transmembrane emp24 domain-containing protein 10
RefSeq ID
NM_006827
RefSeq Synonyms
NM_006827, BC001825, BC001496,
Research Areas
Golgi Apparatus,Immunology,mRNA Processing,RNA Processing,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,genetics,transcription_translation
Species
human
Target Sentence
Transmembrane emp24 domain-containing protein 10 (TMED10) is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity [taken from NCBI Entrez Gene (Gene ID: 10972)].
UniGene ID
Hs.74137
UniProt ID (eCommerce)
P49755

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.