human TLN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TLN1.
shADV-225580
Ad-h-TLN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TLN1 (talin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ILWEQ; talin-1; TLN
Description (eCommerce)
This gene TLN1 encodes for the cytoskeletal protein Talin-1. This protein is concentrated in areas of cell-substratum and cell-cell contacts. Talin-1 plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells [taken from NCBI Entrez Gene (Gene ID: 7094)].
Description (Vector)
TLN1 encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
Gene ID
7094
Gene Name (eCommerce)
talin 1
Gene Name (Vector)
talin 1
Gene Symbol
TLN1
HGNC ID
HGNC:11845
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7626
ORF Size (bp)
7626 bp
Protein Name (eCommerce)
Talin-1
RefSeq ID
NM_006289
RefSeq Synonyms
NM_006289, BC042923,
Research Areas
Angiogenesis,Axon Guidance,Cytoskeleton,EGFR Signaling,Host-Virus Interactions,MAPK Signaling,Neurobiology,Rho Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
This gene TLN1 encodes for the cytoskeletal protein Talin-1. This protein is concentrated in areas of cell-substratum and cell-cell contacts. Talin-1 plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells [taken from NCBI Entrez Gene (Gene ID: 7094)].
UniGene ID
Hs.471014
UniProt ID (eCommerce)
Q9Y490
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.