human TIPRL shRNA silencing Adenovirus

Name 
Ad-h-TIPRL-shRNA
Cat No 
shADV-225541
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TIPRL.

shADV-225541
Ad-h-TIPRL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TIPRL (TOR signaling pathway regulator). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
putative MAPK-activating protein PM10; TIP; TIP41; TIP41, TOR signaling pathway regulator-like; TIP41-like protein; TIPRL1; type 2A-interacting protein
Description (eCommerce)
In Saccharomyces cerevisiae Tip41 is implicated to play a role in the TOR (target of rapamycin) pathway which regulates cell growth in response to nutrient signals. Tip 41 negatively regulates the TOR pathway by binding and inhibiting TAP42, an inhibitor of the SIT4 phosphatase.
Description (Vector)
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 (PubMed 17384681)).(supplied by OMIM, Nov 2010)
Gene ID
261726
Gene Name (eCommerce)
TOR signaling pathway regulator
Gene Name (Vector)
TOR signaling pathway regulator
Gene Symbol
TIPRL
HGNC ID
HGNC:30231
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
537
Protein Name (eCommerce)
TIP41-like protein
RefSeq ID
NM_152902
RefSeq Synonyms
NM_152902, NM_001031800, BC009506,
Research Areas
DNA Damage/Repair,mTOR Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
In Saccharomyces cerevisiae Tip41 is implicated to play a role in the TOR (target of rapamycin) pathway which regulates cell growth in response to nutrient signals. Tip 41 negatively regulates the TOR pathway by binding and inhibiting TAP42, an inhibitor of the SIT4 phosphatase.
UniGene ID
Hs.209431
UniProt ID (eCommerce)
O75663

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.