human TGM2 shRNA silencing Adenovirus

Name 
Ad-h-TGM2-shRNA
Cat No 
shADV-225401
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TGM2.

shADV-225401
Ad-h-TGM2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TGM2 (transglutaminase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C polypeptide, protein-glutamine-gamma-glutamyltransferase; protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGC; tissue transglutaminase; transglutaminase C; transglutaminase H; Transglutaminase-2
Description (eCommerce)
Tissue transglutaminase (TG2) catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21980].
Description (Vector)
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
7052
Gene Name (eCommerce)
transglutaminase 2
Gene Name (Vector)
transglutaminase 2
Gene Symbol
TGM2
HGNC ID
HGNC:11778
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1647
ORF Size (bp)
1647 bp
Protein Name (eCommerce)
Protein-glutamine gamma-glutamyltransferase 2
RefSeq ID
NM_004613
RefSeq Synonyms
NM_198951, NM_004613, NM_001323318, NM_001323317, NM_001323316, BC003551,
Research Areas
Acyltransferase,Apoptosis,Cardiovascular,Huntington's Disease,Immunology,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,NF-kB Signaling,Signal Transduction
Research Areas (Faceted)
cardiovascular,signal_transduction,cell_biology,neurobiology,immunology,metabolism,cell_biology,neurobiology,signal_transduction,immunology
Species
human
Target Sentence
Tissue transglutaminase (TG2) catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21980].
UniGene ID
Hs.517033
UniProt ID (eCommerce)
P21980

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.