human TERT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TERT.
shADV-225313
Ad-h-TERT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TERT (telomerase reverse transcriptase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TP2; TRT
Description (Vector)
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Gene ID
7015
Gene Name (Vector)
telomerase reverse transcriptase
Gene Symbol
TERT
HGNC ID
HGNC:11730
ORF Size (aa)
3363
ORF Size (bp)
3363 bp
RefSeq ID
NM_198253
RefSeq Synonyms
NM_198253, NM_001193376, BC172541, BC156388,
Species
human
UniGene ID
Hs.492203
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.