human TEK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TEK.
shADV-225295
Ad-h-TEK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TEK (TEK receptor tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD202B; TIE-2; TIE2; VMCM; VMCM1
Description (Vector)
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Gene ID
7010
Gene Name (Vector)
TEK receptor tyrosine kinase
Gene Symbol
TEK
HGNC ID
HGNC:11724
ORF Size (aa)
3375
ORF Size (bp)
3375 bp
RefSeq ID
NM_000459
RefSeq Synonyms
NM_001290078, NM_001290077, NM_000459, BC035514,
Species
human
UniGene ID
Hs.89640
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.