human SUV39H1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SUV39H1.
shADV-224768
Ad-h-SUV39H1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SUV39H1 (suppressor of variegation 3-9 homolog 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
H3-K9-HMTase 1; histone H3-K9 methyltransferase 1; histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; KMT1A; lysine N-methyltransferase 1A; MG44; position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; SUV39H
Description (eCommerce)
SUV39H1 (suppressor of variegation 3-9 homolog 1) is a histone methyltransferase that specifically trimethylates histone H3 at lys 9. Trimethylation stimulates the binding of heterochromatin proteins (HPs) which leads to epigenetic transcriptional repression in heterochromatin regions.
Description (Vector)
SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
Gene ID
6839
Gene Name (eCommerce)
suppressor of variegation 3-9 homolog 1
Gene Name (Vector)
suppressor of variegation 3-9 homolog 1
Gene Symbol
SUV39H1
HGNC ID
HGNC:11479
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1239
ORF Size (bp)
1239 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase SUV39H1
RefSeq ID
NM_003173
RefSeq Synonyms
NM_003173, NM_001282166, BC006238,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Epigenetic Regulation of Gene Expression,Histone Modification,Host-Virus Interactions,Methyltransferase,Neurobiology,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,transcription_translation,genetics,infectious_disease,cell_biology,neurobiology,genetics,transcription_translation
Species
human
Target Sentence
SUV39H1 (suppressor of variegation 3-9 homolog 1) is a histone methyltransferase that specifically trimethylates histone H3 at lys 9. Trimethylation stimulates the binding of heterochromatin proteins (HPs) which leads to epigenetic transcriptional repression in heterochromatin regions.
UniGene ID
Hs.522639
UniProt ID (eCommerce)
O43463
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.