human STRADB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human STRADB.
shADV-224634
Ad-h-STRADB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human STRADB (STE20-related kinase adaptor beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038
Description (Vector)
STRADB encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
55437
Gene Name (Vector)
STE20-related kinase adaptor beta
Gene Symbol
STRADB
HGNC ID
HGNC:13205
ORF Size (aa)
1257
ORF Size (bp)
1257 bp
RefSeq ID
NM_018571
RefSeq Synonyms
NM_018571, NM_001206864, BC090871, BC008302,
Species
human
UniGene ID
Hs.652338
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.