human STAT5A shRNA silencing Adenovirus

epididymis secretory sperm binding protein; MGF; signal transducer and activator of transcription 5A; STAT5

Signal transducer and activator of transcription 5a (STAT5a) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones [taken from NCBI Entrez Gene (Gene ID: 6776)].

STAT5A is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

6776

signal transducer and activator of transcription 5A

signal transducer and activator of transcription 5A

STAT5A

HGNC:11366

9606.0

2385

2385 bp

Signal transducer and activator of transcription 5A

NM_003152

NM_003152, NM_001288720, NM_001288719, NM_001288718, BC027036,

Apoptosis,BDNF Signaling,Breast Cancer,Cancer,Cardiovascular,CD40 Signaling,Cell Cycle,Cytokine Signaling,EGFR Signaling,EPO Signaling,FGF Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Leukemia,Metabolism/Metabolic Process,Neurobiology,PDGF Signaling,Prolactin Signaling,RAC1 Signaling,SCF-KIT Signaling,Signal Transduction,TNF Signaling,TPO Signaling,Transcription Factor/Regulator,TSLP Signaling,Viral Carcinogenesis

cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

human

Signal transducer and activator of transcription 5a (STAT5a) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones [taken from NCBI Entrez Gene (Gene ID: 6776)].

Hs.437058

P42229