human ST14 shRNA silencing Adenovirus

Name 
Ad-h-ST14-shRNA
Cat No 
shADV-224454
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ST14.

shADV-224454
Ad-h-ST14-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ST14 (suppression of tumorigenicity 14). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARCI11; HAI; Matriptase; membrane-type serine protease 1; MTSP1; MT-SP1; prostamin; PRSS14; serine protease 14; serine protease TADG-15; SNC19; suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); suppressor of tumorigenicity 14 protein; TADG15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein
Description (eCommerce)
Matriptase/ST14 is an epithelial-derived type II transmembrane trypsin-like serine protease that has been shown to cleave and activate various proteases and growth factors. The overexpression of Matriptase /ST14 in a variety of tumors, and its ability to degrade extracellular matrix suggests a role in tumor invasion.
Description (Vector)
ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Gene ID
6768
Gene Name (eCommerce)
suppression of tumorigenicity 14
Gene Name (Vector)
suppression of tumorigenicity 14
Gene Symbol
ST14
HGNC ID
HGNC:11344
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2568
ORF Size (bp)
2568 bp
Protein Name (eCommerce)
Suppressor of tumorigenicity 14 protein
RefSeq ID
NM_021978
RefSeq Synonyms
NM_021978, BC030532,
Research Areas
Cancer,Metabolism/Metabolic Process,MicroRNAs in Cancer
Research Areas (Faceted)
cancer,cell_biology,genetics,metabolism
Species
human
Target Sentence
Matriptase/ST14 is an epithelial-derived type II transmembrane trypsin-like serine protease that has been shown to cleave and activate various proteases and growth factors. The overexpression of Matriptase /ST14 in a variety of tumors, and its ability to degrade extracellular matrix suggests a role in tumor invasion.
UniGene ID
Hs.504315
UniProt ID (eCommerce)
Q9Y5Y6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.