human SRM shRNA silencing Adenovirus

Name 
Ad-h-SRM-shRNA
Cat No 
shADV-224333
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SRM.

shADV-224333
Ad-h-SRM-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SRM (spermidine synthase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PAPT; putrescine aminopropyltransferase; SPDSY; spermidine synthase; spermidine synthase-1; SPS1; SRML1
Description (eCommerce)
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase (SRM) is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. Spermidine synthase catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor [taken from NCBI Entrez Gene (Gene ID: 6723)].
Description (Vector)
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
Gene ID
6723
Gene Name (eCommerce)
spermidine synthase
Gene Name (Vector)
spermidine synthase
Gene Symbol
SRM
HGNC ID
HGNC:11296
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
909
Protein Name (eCommerce)
Spermidine synthase
RefSeq ID
NM_003132
RefSeq Synonyms
NM_003132, BC033106, BC000309,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase (SRM) is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. Spermidine synthase catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor [taken from NCBI Entrez Gene (Gene ID: 6723)].
UniGene ID
Hs.76244
UniProt ID (eCommerce)
P19623

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.