human SRGN shRNA silencing Adenovirus

Name
Ad-h-SRGN-shRNA

Cat No
shADV-224330

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human SRGN.

shADV-224330

Ad-h-SRGN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SRGN (serglycin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

PPG; PRG; PRG1

Description (Vector)

SRGN encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.

Gene ID

5552

Gene Name (Vector)

serglycin

Gene Symbol

SRGN

HGNC ID

HGNC:9361

ORF Size (aa)

477

RefSeq ID

NM_002727

RefSeq Synonyms

NM_002727, NM_001321054, NM_001321053, BC015516,

Species

human

UniGene ID

Hs.1908

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.