human SPTBN2 shRNA silencing Adenovirus

Name 
Ad-h-SPTBN2-shRNA
Cat No 
shADV-224293
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SPTBN2.

shADV-224293
Ad-h-SPTBN2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SPTBN2 (spectrin beta, non-erythrocytic 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
beta-III spectrin; glutamate transporter EAAT4-associated protein 41; GTRAP41; SCA5; SCAR14; spectrin beta chain, brain 2; spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin, non-erythroid beta chain 2; spinocerebellar ataxia 5 protein
Description (eCommerce)
SPTBN2/SCA5 is a member of the beta spectrin gene family and a subunit of the spectrin cytoskeletal scaffolding protein that links the plasma membrane to cytoskeletal actin and functions in cellular shape and organelle organization. SPTBN2/SCA5 has been identified as a Golgi- and vesicle-associated spectrin. Mutations in SPTBN2/SCA5 cause spinocerebellar ataxia type 5 (SCA5), an autosomal dominant disease characterized by progressive incoordination of gait, hand, speech, and eye movements.
Description (Vector)
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
Gene ID
6712
Gene Name (eCommerce)
spectrin beta, non-erythrocytic 2
Gene Name (Vector)
spectrin beta, non-erythrocytic 2
Gene Symbol
SPTBN2
HGNC ID
HGNC:11276
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7173
ORF Size (bp)
7173 bp
Protein Name (eCommerce)
Spectrin beta chain, non-erythrocytic 2
RefSeq ID
NM_006946
RefSeq Synonyms
NM_006946, BC172438,
Research Areas
Antigen Processing and Presentation,Apoptosis,Axon Guidance,Cytoskeleton,Immunology,Neurobiology,Neurodegeneration,Transport
Research Areas (Faceted)
immunology,cell_biology,neurobiology
Species
human
Target Sentence
SPTBN2/SCA5 is a member of the beta spectrin gene family and a subunit of the spectrin cytoskeletal scaffolding protein that links the plasma membrane to cytoskeletal actin and functions in cellular shape and organelle organization. SPTBN2/SCA5 has been identified as a Golgi- and vesicle-associated spectrin. Mutations in SPTBN2/SCA5 cause spinocerebellar ataxia type 5 (SCA5), an autosomal dominant disease characterized by progressive incoordination of gait, hand, speech, and eye movements.
UniGene ID
Hs.26915
UniProt ID (eCommerce)
O15020

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.