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human SPTA1 shRNA silencing Adenovirus

Name 
Ad-h-SPTA1-shRNA
Cat No 
shADV-224288
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SPTA1.

shADV-224288
Ad-h-SPTA1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SPTA1 (spectrin alpha, erythrocytic 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
EL2; HPP; HS3; SPH3; SPTA
Description (Vector)
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
Gene ID
6708
Gene Name (Vector)
spectrin alpha, erythrocytic 1
Gene Symbol
SPTA1
HGNC ID
HGNC:11272
ORF Size (aa)
7260
ORF Size (bp)
7260 bp
RefSeq ID
NM_003126
RefSeq Synonyms
NM_003126, BC172497, BC156496,
Species
human
UniGene ID
Hs.119825

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.