human SPHK1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SPHK1.
shADV-224167
Ad-h-SPHK1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SPHK1 (sphingosine kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SK 1; sphingosine kinase 1; SPHK; SPK 1
Description (eCommerce)
Sphingosine kinase 1 (SPHK1) catalyzes the phosphorylation of sphingosine to yield sphingosine-1-phosphate (SPP). SPP functions as a lipid signaling molecule that mediates both intra- and extra-cellular responses. SPHK1activity may play a role in several cellular processes such as apoptisis, proliferation, inflammation, and migration.
Description (Vector)
SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
8877
Gene Name (eCommerce)
sphingosine kinase 1
Gene Name (Vector)
sphingosine kinase 1
Gene Symbol
SPHK1
HGNC ID
HGNC:11240
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1413
ORF Size (bp)
1413 bp
Protein Name (eCommerce)
Sphingosine kinase 1
RefSeq ID
NM_182965
RefSeq Synonyms
NM_182965, NM_021972, NM_001142602, NM_001142601, BC030553, BC014439, BC009419, BC008040,
Research Areas
Angiogenesis,Apoptosis,Brain Development,Cancer,Cell Cycle,Fc Receptor Signaling,Immunology,Kinase/Phosphatase,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,PDGF Signaling,Protein Folding,Signal Transduction,Translational Control,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Sphingosine kinase 1 (SPHK1) catalyzes the phosphorylation of sphingosine to yield sphingosine-1-phosphate (SPP). SPP functions as a lipid signaling molecule that mediates both intra- and extra-cellular responses. SPHK1activity may play a role in several cellular processes such as apoptisis, proliferation, inflammation, and migration.
UniGene ID
Hs.68061
UniProt ID (eCommerce)
Q9NYA1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.