human SPAG9 shRNA silencing Adenovirus

Name 
Ad-h-SPAG9-shRNA
Cat No 
shADV-224072
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SPAG9.

shADV-224072
Ad-h-SPAG9-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SPAG9 (sperm associated antigen 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cancer/testis antigen 89; c-Jun NH2-terminal kinase-associated leucine zipper protein; C-Jun-amino-terminal kinase-interacting protein 4; CT89; HLC4; HLC6; HLC-6; human lung cancer oncogene 6 protein; JIP4; JIP-4; JLP; JNK interacting protein; JNK/SAPK-associated protein; JNK-associated leucine-zipper protein; JNK-interacting protein 4; lung cancer oncogene 4; Max-binding protein; mitogen-activated protein kinase 8-interacting protein 4; PHET; PIG6; proliferation-inducing gene 6; Proliferation-inducing protein 6; protein highly expressed in testis; sperm associated antigen 9 variant 5; sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; sunday driver 1
Description (eCommerce)
JLP (JNK-interacting leucine zipper protein) has been identified as a scaffolding protein that functions to position mitogen-activated protein kinases (MAPKs) into specific signaling modules so that successive phosphorylation events of the MAPK pathway can occur. JLP is also known as sperm associated antigen 9 (SPAG9) due to its abundant expression in testicular haploid germ cells.
Description (Vector)
SPAG9 encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.
Gene ID
9043
Gene Name (eCommerce)
sperm associated antigen 9
Gene Name (Vector)
sperm associated antigen 9
Gene Symbol
SPAG9
HGNC ID
HGNC:14524
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3966
ORF Size (bp)
3966 bp
Protein Name (eCommerce)
C-Jun-amino-terminal kinase-interacting protein 4
RefSeq ID
NM_003971
RefSeq Synonyms
NM_003971, NM_001251971, NM_001130528, NM_001130527, BC153878, BC146755, BC007524,
Research Areas
Golgi Apparatus,MAPK Signaling,Neurobiology,Neurodevelopment,Signal Transduction,Spermatogenesis,TNF Signaling
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
JLP (JNK-interacting leucine zipper protein) has been identified as a scaffolding protein that functions to position mitogen-activated protein kinases (MAPKs) into specific signaling modules so that successive phosphorylation events of the MAPK pathway can occur. JLP is also known as sperm associated antigen 9 (SPAG9) due to its abundant expression in testicular haploid germ cells.
UniGene ID
Hs.463439
UniProt ID (eCommerce)
O60271

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.