human SOS2 shRNA silencing Adenovirus

Name 
Ad-h-SOS2-shRNA
Cat No 
shADV-224004
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SOS2.

shADV-224004
Ad-h-SOS2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
guanine nucleotide releasing factor; NS9; son of sevenless homolog 2; SOS-2
Description (eCommerce)
SOS2 (son of sevenless homolog 2) is a human paralog of the Drosophila SOS gene. Drosophila SOS was originally identified as a gene that functioned downstream of the sevenless gene in the Ras/MAP kinase signaling pathway. SOS and its paralogs, SOS1 and SOS2, function as guanine nucleotide exchange factors that act on Ras-GTPases to cause release of GDP in exchange for GTP. Although targeted disruption of SOS1 results in embryonic lethality, disruption of SOS2 does not have any effects on mouse development, growth, or fertility.
Gene ID
6655
Gene Name (eCommerce)
SOS Ras/Rho guanine nucleotide exchange factor 2
Gene Name (Vector)
SOS Ras/Rho guanine nucleotide exchange factor 2
Gene Symbol
SOS2
HGNC ID
HGNC:11188
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3900
ORF Size (bp)
3900 bp
Protein Name (eCommerce)
Son of sevenless homolog 2
RefSeq ID
NM_006939
RefSeq Synonyms
NM_006939, BC143367, BC143366, BC117261,
Research Areas
Apoptosis,Axon Guidance,B-cell Receptor Signaling,Breast Cancer,Cancer,Cytoskeleton,DNA Damage/Repair,EGFR Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,GnRH Signaling,GPCR Signaling,HGF Signaling,Host-Virus Interactions,Immunology,Insulin Signaling,JAK-STAT Signaling,Kidney Cancer,Leukemia,Lung Cancer,MAPK Signaling,MicroRNAs in Cancer,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,Rho Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
SOS2 (son of sevenless homolog 2) is a human paralog of the Drosophila SOS gene. Drosophila SOS was originally identified as a gene that functioned downstream of the sevenless gene in the Ras/MAP kinase signaling pathway. SOS and its paralogs, SOS1 and SOS2, function as guanine nucleotide exchange factors that act on Ras-GTPases to cause release of GDP in exchange for GTP. Although targeted disruption of SOS1 results in embryonic lethality, disruption of SOS2 does not have any effects on mouse development, growth, or fertility.
UniGene ID
Hs.291533
UniProt ID (eCommerce)
Q07890

Recently Viewed Products

Ad-h-SOD2

Cat No: ADV-223982

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.