human SMC6 shRNA silencing Adenovirus

Name
Ad-h-SMC6-shRNA

Cat No
shADV-223740

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human SMC6.

shADV-223740

Ad-h-SMC6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SMC6 (structural maintenance of chromosomes 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

No

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

hSMC6; SMC protein 6; SMC-6; SMC6 structural maintenance of chromosomes 6-like 1; SMC6L1; structural maintenance of chromosomes protein 6

Description (eCommerce)

SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.

Gene ID

79677

Gene Name (eCommerce)

structural maintenance of chromosomes 6

Gene Name (Vector)

structural maintenance of chromosomes 6

Gene Symbol

SMC6

HGNC ID

HGNC:20466

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3276

ORF Size (bp)

3276 bp

Protein Name (eCommerce)

Structural maintenance of chromosomes protein 6

RefSeq ID

NM_024624

RefSeq Synonyms

NM_024624, NM_001142286, BC039828,

Research Areas

DNA Damage/Repair,Telomeric Maintenance

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.

UniGene ID

Hs.526728

UniProt ID (eCommerce)

Q96SB8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.