human SMC4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SMC4.
shADV-223738
Ad-h-SMC4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SMC4 (structural maintenance of chromosomes 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAPC; CAP-C; chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes protein 4; XCAP-C homolog
Description (eCommerce)
SMC (Structural maintenance of chromosomes) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
Description (Vector)
Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.(supplied by OMIM, Nov 2010)
Gene ID
10051
Gene Name (eCommerce)
structural maintenance of chromosomes 4
Gene Name (Vector)
structural maintenance of chromosomes 4
Gene Symbol
SMC4
HGNC ID
HGNC:14013
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3867
ORF Size (bp)
3867 bp
Protein Name (eCommerce)
Structural maintenance of chromosomes protein 4
RefSeq ID
NM_005496
RefSeq Synonyms
NM_005496, NM_001288753, NM_001002800, BC148796, BC146370,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
SMC (Structural maintenance of chromosomes) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
UniGene ID
Hs.58992
UniProt ID (eCommerce)
Q9NTJ3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.