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human SMC2 shRNA silencing Adenovirus

Name 
Ad-h-SMC2-shRNA
Cat No 
shADV-223734
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SMC2.

shADV-223734
Ad-h-SMC2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SMC2 (structural maintenance of chromosomes 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CAPE; CAP-E; chromosome-associated protein E; hCAP-E; SMC protein 2; SMC-2; SMC2 (structural maintenance of chromosomes 2, yeast)-like 1; SMC2L1; structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E; structural maintenance of chromosomes protein 2; XCAP-E homolog
Description (eCommerce)
Structural maintenance of chromosomes (SMC) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
Description (Vector)
Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.(supplied by OMIM, Nov 2010)
Gene ID
10592
Gene Name (eCommerce)
structural maintenance of chromosomes 2
Gene Name (Vector)
structural maintenance of chromosomes 2
Gene Symbol
SMC2
HGNC ID
HGNC:14011
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3594
ORF Size (bp)
3594 bp
Protein Name (eCommerce)
Structural maintenance of chromosomes protein 2
RefSeq ID
NM_006444
RefSeq Synonyms
NM_006444, NM_001265602, NM_001042551, NM_001042550, BC144163, BC130385,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Structural maintenance of chromosomes (SMC) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
UniGene ID
Hs.119023
UniProt ID (eCommerce)
O95347

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.