human SMARCE1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SMARCE1.
shADV-223729
Ad-h-SMARCE1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SMARCE1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; CSS5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Description (eCommerce)
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. BAF57/SMARCE1 is a core subunit found in all SWI/SNF complexes. The BAF57/SMARCE1 subunit has been demonstrated to interact with the estrogen receptor (ER) and is required for the coactivation of ER-mediated gene transcription.
Description (Vector)
SMARCE1 is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
Gene ID
6605
Gene Name (eCommerce)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Gene Name (Vector)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Gene Symbol
SMARCE1
HGNC ID
HGNC:11109
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1236
ORF Size (bp)
1236 bp
Protein Name (eCommerce)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
RefSeq ID
NM_003079
RefSeq Synonyms
NM_003079, BC063700, BC011017, BC007082,
Research Areas
Chromatin Remodeling,Neurobiology,Neurodevelopment,Neurogenesis,Nuclear Receptor Coactivators,Signal Transduction,TNF Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,transcription_translation,neurobiology,developmental_biology,cell_biology,signal_transduction,genetics,transcription_translation
Species
human
Target Sentence
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. BAF57/SMARCE1 is a core subunit found in all SWI/SNF complexes. The BAF57/SMARCE1 subunit has been demonstrated to interact with the estrogen receptor (ER) and is required for the coactivation of ER-mediated gene transcription.
UniGene ID
Hs.696086
UniProt ID (eCommerce)
Q969G3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.