human SMAD3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SMAD3.
shADV-223691
Ad-h-SMAD3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SMAD3 (SMAD family member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; MAD, mothers against decapentaplegic homolog 3; mad3; MADH3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD 3; SMAD family member 3; SMAD, mothers against DPP homolog 3; Smad3
Description (eCommerce)
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. [taken from NCBI Entrez Gene (Gene ID: 4088)].
Description (Vector)
SMAD3 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
Gene ID
4088
Gene Name (eCommerce)
SMAD family member 3
Gene Name (Vector)
SMAD family member 3
Gene Symbol
SMAD3
HGNC ID
HGNC:6769
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1278
ORF Size (bp)
1278 bp
Protein Name (eCommerce)
Mothers against decapentaplegic homolog 3
RefSeq ID
NM_005902
RefSeq Synonyms
NM_005902, NM_001145104, NM_001145103, NM_001145102, BC050743, BC000414,
Research Areas
Apoptosis,Autophagy,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Colorectal Cancer,DNA Damage/Repair,EGFR Signaling,Gene Expression,Hippo Signaling,Host-Virus Interactions,Hypoxia,Immunology,Leukemia,Prostate Cancer,RNA Processing,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. [taken from NCBI Entrez Gene (Gene ID: 4088)].
UniGene ID
Hs.714621
UniProt ID (eCommerce)
P84022
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.