human SKP1 shRNA silencing Adenovirus

Name 
Ad-h-SKP1-shRNA
Cat No 
shADV-223049
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SKP1.

shADV-223049
Ad-h-SKP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SKP1 (S-phase kinase associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L
Description (Vector)
SKP1 encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Gene ID
6500
Gene Name (Vector)
S-phase kinase associated protein 1
Gene Symbol
SKP1
HGNC ID
HGNC:10899
ORF Size (aa)
492
RefSeq ID
NM_006930
RefSeq Synonyms
NM_170679, NM_006930, BC065730, BC025673, BC020798, BC009839,
Species
human
UniGene ID
Hs.710433

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.