human SIP1 shRNA silencing Adenovirus

Name 
Ad-h-SIP1-shRNA
Cat No 
shADV-223007
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GEMIN2.

shADV-223007
Ad-h-SIP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GEMIN2 (gem nuclear organelle associated protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
component of gems 2; gem-associated protein 2; gemin-2; SIP1; SIP1-delta; SMN interacting protein 1-delta; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1
Description (eCommerce)
GEMIN2 found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. GEMIN2 interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex [taken from NCBI Entrez Gene (Gene ID: 8487)].
Description (Vector)
GEMIN2 encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Gene ID
8487
Gene Name (eCommerce)
gem nuclear organelle associated protein 2
Gene Name (Vector)
gem nuclear organelle associated protein 2
Gene Symbol
GEMIN2
HGNC ID
HGNC:10884
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
843
ORF Size (bp)
843 bp
Protein Name (eCommerce)
Gem-associated protein 2
RefSeq ID
NM_003616
RefSeq Synonyms
NM_003616, NM_001009183, NM_001009182, BC104968,
Research Areas
Gene Expression,Immunology,mRNA Processing,mRNA Splicing,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
immunology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
GEMIN2 found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. GEMIN2 interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex [taken from NCBI Entrez Gene (Gene ID: 8487)].
UniGene ID
Hs.708127
UniProt ID (eCommerce)
O14893

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.