human SIAH1 shRNA silencing Adenovirus

Name
Ad-h-SIAH1-shRNA

Cat No
shADV-222980

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human SIAH1.

shADV-222980

Ad-h-SIAH1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SIAH1 (siah E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

SIAH1A

Description (Vector)

SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Gene ID

6477

Gene Name (Vector)

siah E3 ubiquitin protein ligase 1

Gene Symbol

SIAH1

HGNC ID

HGNC:10857

ORF Size (aa)

942

RefSeq ID

NM_003031

RefSeq Synonyms

NM_003031, NM_001006610, BC044920, BC042550, BC035562,

Species

human

UniGene ID

Hs.295923

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.