human SHPK shRNA silencing Adenovirus

Name 
Ad-h-SHPK-shRNA
Cat No 
shADV-222960
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SHPK.

shADV-222960
Ad-h-SHPK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SHPK (sedoheptulokinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
carbohydrate kinase-like protein; CARKL; sedoheptulokinase; SHK
Description (eCommerce)
Sedoheptulokinase (SHPK) acts as a modulator of macrophage activation through control of glucose metabolism [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHJ6].
Description (Vector)
SHPK has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.
Gene ID
23729
Gene Name (eCommerce)
sedoheptulokinase
Gene Name (Vector)
sedoheptulokinase
Gene Symbol
SHPK
HGNC ID
HGNC:1492
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1437
ORF Size (bp)
1437 bp
Protein Name (eCommerce)
Sedoheptulokinase
RefSeq ID
NM_013276
RefSeq Synonyms
NM_013276, BC020543,
Research Areas
Immunology,Interleukin Signaling,Metabolism/Metabolic Process,Signal Transduction
Research Areas (Faceted)
cell_biology,immunology,metabolism,signal_transduction
Species
human
Target Sentence
Sedoheptulokinase (SHPK) acts as a modulator of macrophage activation through control of glucose metabolism [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHJ6].
UniGene ID
Hs.579217
UniProt ID (eCommerce)
Q9UHJ6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.