human SFTPB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SFTPB.
shADV-222829
Ad-h-SFTPB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SFTPB (surfactant protein B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PSP-B; SFTB3; SFTP3; SMDP1; SP-B
Description (Vector)
SFTPB encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
Gene ID
6439
Gene Name (Vector)
surfactant protein B
Gene Symbol
SFTPB
HGNC ID
HGNC:10801
ORF Size (aa)
1146
ORF Size (bp)
1146 bp
RefSeq ID
NM_000542
RefSeq Synonyms
NM_198843, NM_000542, BC032785,
Species
human
UniGene ID
Hs.512690
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.